The study aims to reflect on the training of future primary school teachers by starting from the use of the e-portfolio as an innovative tool to promote the acquisition of reflective and self-evaluation competence within the flipped classroom. The research, involved 154 students of Primary Education Master’s Degree Course of the University of Palermo, attending to the Docimology course during the academic year 2020/2021. This paper presents the theoretical assumptions, objectives and operating methods of a path that made the use of the e-portfolio in flipped classroom to promote the development of docimological skills in higher education. It was hypothesized that the training intervention designed according to the principles of the flipped methodology and through the use of the e-portfolio, would have contributed to the development of students’ self-evaluation skills during the 30 hours of the Docimology course.